The United States has withdrawn midfielders Michael Bradley and Mix Diskerud and defender Tim Ream from the squad that will face Ukraine on Wednesday in a friendly in Cyprus.
Bradley is preparing for his first season with Toronto FC. He scored for his new club in a preseason exhibition Saturday.
U.S. Soccer said in a release that Bradley "will stay behind to receive treatment for a minor issue" instead of playing for the national team.
Bradley would have been the only MLS-based player to make the trip other than Clint Dempsey, who just completed a loan spell with England's Fulham on Saturday.
The U.S. also said Diskerud would miss out while "returning to full fitness following a right hip injury suffered 10 days ago," but a tweet by Diskerud told a different story.
Diskerud wrote that his club team, Rosenborg in Norway, declined to release him for the friendly.
RBK didn't wish to release me today US honored objection- Prior camp outside FIFAd ME- very disappointed G'luck everyone else— Mix Diskerud (@MixDiskerud) March 1, 2014
The U.S. Soccer release did not mention any sort of agreement with the club to retain Diskerud. The Norwegian Tippeligaen season does not begin until the end of March, though Rosenborg has a preseason friendly against a second-division Norwegian team set for Thursday.
Ream, who plays for Bolton in England, was excused for personal reasons, U.S. soccer said.
The U.S. will not replace the three players. The remaining roster for the Ukraine friendly:
Goalkeepers: Cody Cropper (Southampton), Brad Guzan (Aston Villa), Tim Howard (Everton)
Defenders: John Brooks (Hertha Berlin), Geoff Cameron (Stoke City), Edgar Castillo (Club Tijuana), Alfredo Morales (Ingolstadt), Oguchi Onyewu (Sheffield Wednesday), Will Packwood (Birmingham City)
Midfielders: Alejandro Bedoya (Nantes), Fabian Johnson (Hoffenheim), Jermaine Jones (Besiktas), Sacha Kljestan (Anderlecht), Brek Shea (Barnsley), Danny Williams (Reading)
Forwards: Juan Agudelo (Utrecht), Jozy Altidore (Sunderland), Terrence Boyd (Rapid Vienna), Clint Dempsey (Seattle Sounders FC), Julian Green (Bayern Munich), Aron Johannsson (AZ Alkmaar)