Boos rang out at Wembley for the second time in four days as Per Mertesacker's header condemned England to defeat against Germany, while Spain were beaten by South Africa in the same stadium where they won the 2010 World Cup.
Following Friday’s loss to Chile, the Three Lions’ 1-0 defeat to the Nationalmannschaft meant they had endured back-to-back home losses for the first time in 36 years.
England held their own for the majority of the first half, but Germany goalkeeper Roman Weidenfeller was nothing but a spectator until Andros Townsend struck a post during the hosts' first real threatening effort just before the hour.
Despite the lack of attempts on Germany's goal, defensive worries will be England manager Roy Hodgson's worry during the four-month break from international football.
Mertesacker lost his marker and nodded home Mario Gotze's cross towards the end of the first half, just as Alexis Sanchez had done on Friday when Chile won 2-0.
Had it not been for Joe Hart, who performed superbly on his return to action, Joachim Low's men could have had four.
Meanwhile, in Johannesburg, South Africa claimed a shock 1-0 win over reigning world and European champions Spain at Soccer City stadium.
A second-half goal by Bernard Parker earned the South Africans a surprise triumph as he beat Victor Valdes after 57 minutes to stun Vicente del Bosque's side, who produced one of their poorest performances in recent memory to lose only their second match in more than three years.
Controversy reigned in the final quarter of an hour when Valdes became injured after Del Bosque had made all of his substitutions, but Pepe Reina was allowed to come on and replace the Barcelona goalkeeper, despite protests from the South Africa dugout.
Elsewhere, Netherlands, the side Spain beat in the 2010 World Cup final to be crowned champions, were held to a 0-0 draw by Colombia at the Amsterdam ArenA.
The Oranje had to play almost an hour with a man less following Jeremain Lens' red card but they still managed to stretch their unbeaten run to 17 games.
Lens was given a straight red for a poor tackle on Pablo Armero after 35 minutes and Netherland’s night got worse before the break as both Rafael van der Vaart and Siem de Jong were forced off injured.
Despite that, they held on for the draw after the break with Colombia's star striker Radamel Falcao becalmed throughout.
Belgium, a side widely tipped to do well in next year's World Cup, suffered their second successive friendly loss as they were beaten 3-2 by Japan having also been downed by the Colombians on Friday.
The Red Devils scored first and last through Kevin Mirallas and Toby Alderweireld but Japan struck three times in between through Yoichiro Kakitani, Keisuke Honda and Shinji Okazaki.
Gibraltar drew 0-0 with Slovakia in their first international match since being accepted by UEFA as a full member earlier this year.
The British Overseas Territory, which lies off the south coast of Spain, became the 54th nation to join European football's governing body in May.
There had been opposition from Spain but the Gibraltar FA won a case at the Court of Arbitration for Sport obliging UEFA to accept them as a member.
Their historic first match was staged at the Estadio de Algarve in neighbouring Portugal this evening and Allen Bula's men claimed a creditable goalless draw against a Slovakia side placed 65th in FIFA's world rankings.
In other friendlies, Russia battled back from a goal down to beat South Korea 2-1, Turkey snatched a late 2-1 win over Belarus, while Austria saw off the USA 1-0 courtesy of a first-half Marc Janko effort.
Elsewhere, Slovenia beat Canada 1-0, Malta defeated Faroe Islands 3-2 and Estonia were 3-0 victors at Liechtenstein. Ecuador held Honduras to a 2-2 draw, despite the sending off of Juan Carlos Parades.
Information from the Press Association was used in this report