Italy scored twice in the opening 10 minutes and Antonio Conte got the better of Guus Hiddink in coaching debuts for both men as a 10-man Netherlands were beaten 2-0 in a friendly on Thursday.
Ciro Immobile scored his first international goal three minutes in, and Daniele De Rossi added a penalty in the 10th.
The opening goal was set up by a long, vertical pass from defender Leonardo Bonucci, which Immobile controlled expertly then dribbled around goalkeeper Jasper Cillessen before slotting into an empty net.
The penalty was awarded after Bruno Martins Indi was sent off for pushing down Simone Zaza, and De Rossi converted a soft shot into the left corner as Cillessen dove the other way.
Netherlands rarely threatened at San Nicola Stadium.