Hull manager Steve Bruce insisted all was not lost despite a 2-0 defeat to Tottenham leaving his side on the brink of relegation from the Premier League.
Second-half goals from Nacer Chadli and Danny Rose mean the Tigers are two points adrift of safety and must win at home to Bruce's old club Manchester United next weekend.
Even victory against Louis van Gaal's side may not be enough, however, with Newcastle and Sunderland currently two and three points ahead respectively.
Sunderland, who also have a game in hand at Arsenal on Wednesday, visit Chelsea on the last day while Newcastle host West Ham.
"It's not lost," Bruce said. "We've got to beat Man United and I haven't done that in 17 years. I've got to turn the tables.
"Maybe there's a twist in it, maybe Man United owe me something after wrecking my knee and my hip and my ankle. We have to try to be positive."
The defeat to Tottenham capped a miserable seven days for Hull, who lost at home to Burnley last weekend before being hit with the news Jake Livermore had been suspended, reportedly for testing positive for cocaine.
Livermore, who has been suspended by the Football Association and his club, missed the match at White Hart Lane and could face a ban of up to two years.
Bruce said he broke the news to Livermore of the failed test on Wednesday, and said his player "is obviously in a dark place.''
"I can't come to terms with it, if I'm being honest," Bruce said on Saturday after his team's 2-0 loss to Tottenham in the English Premier League. "The conversation I had with him is the hardest conversation I've ever had with any footballer.
"The week has been arguably the worst week I've had in terms of the result last week and then of course the shocking news of what fell on our laps on Wednesday.
"The team and their response today has been magnificent and I couldn't have asked for anything more. I couldn't have asked for them to play any better after the woeful performance last week.
"The frustration is how we produced what we produced last week and what we produced today.
"The reason we're in the bottom three is pretty evident today. We've had five or six really glorious opportunities and at this level you've got to take them."