Borussia Dortmund have suffered another injury blow after midfielder Henrikh Mkhitaryan was ruled out for four weeks due to an ankle injury sustained in the final minute of Saturday's 2-0 defeat at Mainz.
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Only four days on from the impressive 2-0 Champions League victory over Arsenal, Dortmund suffered a setback in the Bundesliga, with their opponents sending them home empty-handed.
Jurgen Klopp's side conceded two goals in the second half and, when 1-0 down, striker Ciro Immobile failed to convert a penalty.
"It all went wrong for us, and that's why we ended up the deserved losers," Klopp told his postmatch news conference.
The weekend soon went from bad to worse for Klopp when the club announced on Sunday that Mkhitaryan suffered a bone injury in the final minutes of the game.
"The Armenia international is expected to be out for four weeks," Dortmund announced on their official website.
Mkhitaryan is the sixth Dortmund midfielder to have been ruled out for a lengthy period after Marco Reus, Jakub Blaszczykowski, Ilkay Gundogan, Nuri Sahin and Oliver Kirch all sustained injury problems.
After hosting Stuttgart on Wednesday, Dortmund then play rivals Schalke in the Revierderby at the Veltins Arena on Saturday.
Their opponents have also suffered with injuries since the World Cup, and are currently without a number of key players, such as Benedikt Howedes and Jefferson Farfan.
The Royal Blues are also set to be without Julian Draxler, one of two players shown a red card by referee Markus Schmidt during the 2-2 draw with Eintracht Frankfurt.
While Kevin-Prince Boateng was sent off after receiving two yellow cards, Draxler was shown a straight red for violent conduct against Carlos Zambrano.
On his 21st birthday, Draxler had first levelled the score as the Royal Blues came back from 2-0 down, before receiving his marching orders in the 71st minute.
According to German Football Association (DFB) statutes, he was initially set for a three-match ban. However, kicker reported that the Royal Blues hoped to have the suspension reduced to two games, arguing that the midfielder was provoked by Zambrano.
The DFB eventually followed that line of argument and handed Draxler a reduced ban.
"There is no need to discuss it. But it was a reflex action and not out of malice," Schalke sporting executive Horst Heldt told reporters of Draxler's actions after Saturday's game. "He was full of adrenaline and moreover we were already down to 10 men and Julian had scored -- a lot of things can explode. It has happened to others before."