Rafael van der Vaart and Marcell Jansen have been told they do not have futures with Hamburg.
Both will be out of contract in the summer and neither will be offered new terms, the Bundesliga club's director of sport Dietmar Beiersdorfer said.
Meanwhile, Heiko Westermann and Slobodan Rajkovic face uncertainty over their futures.
"Rafael and Marcell know that we are not going to hold any talks with them over contract extensions," Beiersdorfer told his club's official website.
"With Heiko and Slobodan,...