Coupe de France surprise packages Yzeure and Monts d'Or Azergues have been rewarded for their last-64 exploits with eye-catching draws against Lyon and Monaco in the next round.
Paris St Germain, meanwhile, will face Ligue 1 rivals Montpellier if they come through their clash with second-division Brest, which has been postponed for a second time due to a waterlogged pitch and will now be played on Wednesday evening.
Yzeure inflicted a first defeat in nine games on in-form Ligue 1 side Lorient on Saturday and will now get a visit from Europa League group winners Lyon.
MDA, the Chasselay-based minnows counting former France international Ludovic Giuly among their ranks, beat Ligue 2 Istres and will host big-spending Monaco -- the top flight's second-placed side, in their first season after promotion.
Marseille and Nice meet in the only confirmed clash between Ligue 1 sides.
Iris Club Croix and L'Ile Rousse, both from the fifth tier, will each face high-flying Ligue 1 opposition in the respective forms of third-placed Lille and fourth-placed Bordeaux.
Ajaccio host Caen while the other Ligue 1 teams already through -- Bastia, Toulouse, Sochaux, Rennes and Guingamp -- travel to Lens, Moulins, Angers, Boulogne and Concarneau respectively.
Auxerre face Dijon and Bastia host Niort.
Two more last-64 ties are still to be resolved, with Jura Sud and Creteil playing on Wednesday to earn a trip to Sete, and St Etienne taking on Cannes next Tuesday, with fourth-tier Plabennec awaiting the winners.