David Silva was not included in the Manchester City squad to face Manchester United, who will start Marcus Rashford up front with Wayne Rooney on the bench.
Spain international Silva was forced off after just 23 minutes of Sunday's FA Cup semifinal loss to Arsenal with a hamstring injury, having been hit hard by a tackle moments earlier.
Sergio Aguero starts despite suffering a knock in the same game, while Gabriel Jesus is on the bench as he looks to regains full match fitness.
Raheem Sterling returns to the starting XI, while Jesus Navas is on the bench following the return of Pablo Zabaleta and Aleksandar Kolarov.
Rashford leads the line for United, while Anthony Martial again starts rather than Jesse Lingard, and Henrikh Mkhitaryan is set up behind the striker.
Daley Blind and Matteo Darmian get the nods on United's injury-hit back line, along with Eric Bailly and Antonio Valencia.
Paul Pogba is not in the squad as expected because of a muscle injury suffered against Burnley at the weekend.
Man City XI: Bravo; Zabaleta, Kompany, Otamendi, Kolarov; Toure, Fernandinho; Sterling, De Bruyne, Sane; Aguero
Bench: Caballero; Sagna, Fernando, Navas, Clichy, Gabriel Jesus, Garcia
Man United XI: De Gea; Valencia, Bailly, Blind, Darmian; Herrera, Carrick, Fellaini; Martial, Mkhitaryan, Rashford
Bench: Romero; Shaw, Fosu-Mensah, Tuanzebe, Young, Lingard, Rooney