Sutton United provided the biggest upset of the FA Cup fourth round with a stunning 1-0 win over Leeds United.
Captain Jamie Collins scored the winner from the penalty spot as the lowest-ranked side in the competition shocked the Championship high-flyers.
No less than 83 places separated these teams but Leeds manager Garry Monk, clearly concentrating on promotion back to the Premier League, paid the price for making 10 changes to his line-up.
Bastian Schweinsteiger marked his first start in over a year with a goal and an assist as Manchester United beat Wigan 4-0 to advance to the fifth round.
Schweinsteiger, starting his first game for United since Jan. 9, 2016, helped break the deadlock for the hosts on the stroke of half-time -- crossing for Marouane Fellaini, who towered above his marker to head home.
Wigan threatened to pull level shortly after the break, with Sergio Romero's clearance falling kindly to David Perkins, but the Red Devils keeper recovered well to keep out the midfielder's low strike.
United, however, doubled their lead on 57 minutes, with Chris Smalling finding the back of the net through a header from an Anthony Martial cross.
Henrikh Mkhitaryan made sure of the result after 74 minutes, playing the ball into Martial before racing into the box to get on the end of his cross to tap in from close range.
And Schweinsteiger completed the scoring nine minutes from time, striking home on the turn after Ander Herrera had nodded down a corner into his path.
Elsewhere, Fulham will join them in the next round after a 4-1 win over Premier League side Hull City.
The hosts put four past a Hull outfit who looked lethargic throughout the game with former Tigers forward Sone Aluko opening the scoring for Fulham just 17 minutes in.
The Tigers equalised shortly after half-time through Lazar Markovic but goals from Chris Martin, Ryan Sessegnon and Stefan Johansen put the game to bed before Hull striker Abel Hernandez failed to convert two late penalty kicks at Craven Cottage.
Millwall recorded a 1-0 home victory over Watford that took them into the fifth round.
Another convincing performance was finally rewarded with the goal it deserved when Steve Morison's late, close-range finish ensured Watford became the second Premier League team the hosts have eliminated this season after Bournemouth, whom they beat 3-0 in the third round.