The FA Cup fifth-round draw took place on Monday and the last-16 matchups include an Arsenal visit to surprise package Sutton United as well as holders Manchester United travelling to face Blackburn Rovers.
The National League side earned rich reward for their defeat of Championship Leeds on Sunday when they were handed a visit from Arsene Wenger's side.
National League leaders Lincoln will also face top-flight opposition as they travel to Burnley. Lincoln have already beaten three league sides in Oldham, Ipswich and Championship leaders Brighton during their cup run.
It is the first time in the history of the competition two non-League sides have reached the last 16.
Sutton's clash will see Wenger take his men to the 5,000-capacity Gander Green Lane to play on United's 3G pitch.
Sutton manager Paul Doswell told Sky Sports News: "I have just picked myself back up off the floor -- a plum, plum game for us against one of the best sides in England, if not Europe. To imagine Arsenal will be coming to our stadium, our Gander Green Lane little fortress, is just incredible.
"We talked about the Wimbledon game being our cup final, then the Leeds game being like the European Cup final, so this is going to be like the World Cup final. It is as big as that for us.''
Sutton have not revelled in such glory since famously beating Coventry, cup winners two years previously, in 1989.
"The profile of the club has risen so much in the last six to eight weeks,'' said Doswell. "It's a massive credit to our players and at least half of them support Arsenal, and about three of them have played for Arsenal.''
Elsewhere in the draw, Wolves' reward for knocking out Liverpool on Saturday is a home clash with Premier League leaders Chelsea. Oxford, who also pulled off a giant-killing against Championship high-flyers Newcastle, will travel to Middlesbrough.
Tottenham, after surviving a scare against Wycombe, face an all-London clash at Fulham while Manchester City will make the short journey Huddersfield.
The final tie of the round will see League One Millwall, conquerors of Watford, host the winners of the replay between Derby and Premier League champions Leicester.
Ties to be played the weekend of Feb. 18: