Salomon Rondon's first-half effort helped Venezuela to a surprise 1-0 win over Uruguay in Philadelphia on Thursday.
Rondon's 36th-minute goal gave Venezuela two wins from two and left Uruguay sitting at the bottom of Group C with zero points and with no hope of qualifying for the quarterfinals.
Venezuela went ahead when Alejandro Guerra spotted Uruguay goalkeeper Fernando Muslera off his line and launched an audacious 50-yard effort that Muslera did well to tip onto the crossbar but Rondon was alert to the rebound and reacted quickest to turn the ball into the net.
Edinson Cavani, who had gone close twice in the first half, should have equalised a minute from time but fired narrowly wide when through one-on-one with Daniel Hernandez.
In Thursday's other match, Mexico ensured their progression to the quarterfinals with a 2-0 defeat of Jamaica.
Jamaica had the first quality chance in front of a packed Rose Bowl in the seventh minute, but Clayton Donaldson's right-footed shot flashed just wide of Guillermo Ochoa's far post after being played in with only the Mexico keeper to beat.
Mexico capitalised 11 minutes later through a fine Chicharito Hernandez strike.
From a Jesus Corona cross on the left, the Bayer Leverkusen striker snapped his header past a diving Andre Blake, who got a touch but couldn't keep the ball out at his far post.
Oribe Peralta then sealed the win -- and a place in the knockout stage -- with a rolled, left-footed shot to the far post in the 81st minute.
Mexico will play Venezuela on Monday in Houston to determine final Group C seeding.