River Plate have announced that Camilo Mayada and Lucas Martinez Quarta, tested positive for a banned substance during Copa Libertadores.
Every team's path is laid out, and the draw is set up to deliver one team from Brazil and one from Argentina to meet in the Copa Libertadores final.
There were major surprises and disappointments in the Copa Libertadores group stage, with Brazil and Argentina clubs looking strong for the last-16.
Brazilian club docked three points for fielding a suspended player.
Colombia's Santa Fe and The Strongest of Bolivia go head-to-head while other clubs need help to make the knockout rounds of the Copa Libertadores.
Chapecoense face expulsion from the Copa Libertadores after allegedly playing an ineligible player on Wednesday.