Trailing 3-0 on aggregate, Borussia Monchengladbach stormed back with four unanswered goals to shock Fiorentina.
Vyacheslav Karavev finally put Sparta Prague on the scoreboard, but Rostov advance to the next round on 5-1 aggregate.
Despite several late chances for Ludogorets, Copenhagen saw out their 2-1 1st-leg lead and advanced via a goalless 2nd leg.
Borja Valero scored with ease for Fiorentina after Borussia's Jannik Vestergaard whiffed as he attempted to clear the ball.
Spurs crash out of the round of 32 after conceding twice at home and going down to ten men after Dele Alli was sent off.
Anderlecht striker Isaac Kiese Thelin says he lives for moments like his dramatic late goal versus Zenit.