Erick Torres scored two late goals to give the Houston Dynamo a share of the points in a thrilling 3-3 draw against FC Dallas.
Sebastian Giovinco netted a stunning free-kick and Toronto FC never looked back, defeating the Philadelphia Union 3-0.
LA Galaxy fell prey to VAR and a dominant performance from Columbus, despite two penalty saves from Jon Kempin.
Major League Soccer: Jozy Altidore (57') Toronto FC 3-0 Philadelphia Union
Major League Soccer: Justin Meram (90') Columbus Crew SC 2-0 LA Galaxy
D.C. United relied on an own goal off the body of Michael Parkhurst to see off Atlanta United at RFK Stadium.