Celta Vigo and Standard Liege had to settle for a draw in their Group G Europa League match.
Gent came back twice against Braga in their Group H match of the Europa League.
Lasse Schone's freekick was the pick of the goals in their 2-0 victory over Panathinaikos in the Europa League.
Bernard's tidy finish in the 74th minute capped a dominant 4-0 win for Shakhtar over Konyaspor.
Steaua Bucuresti's 2-1 victory against Osmanlispor give them hope to stay in the UEFA Europa League.
Fiorentina's unbeaten run in the Europa League group stage ended at seven after PAOK earned a 3-2 win in Florence.