Portland's final MLS match and their Champions League clash with Saprissa carry equal weight for Caleb Porter.
FC Dallas missed an opportunity to make the knockout rounds of the CCL with a 0-0 draw vs. Suchitepequez, while Tigres suffered a shock defeat.
The New York Red Bulls secured passage to the knockout round of the CONCACAF Champions League with a 0-0 draw against Antigua.
Sacha Kljestan scored a late goal to help the New York Red Bulls beat Alianza FC 1-0 in Group F play of the CONCACAF Champions League.
Saprissa beat the Portland Timbers 4-2 in their Group B match of the CONCACAF Champions League on Wednesday night.
The Vancouver Whitecaps beat Sporting KC 2-1 in a CONCACAF Champions League game marred by a weather delay, and Pachuca beat Police United 11-0.