Strasbourg and Amiens were promoted to Ligue 1 on Friday following an incredibly tight race in the French second division.
Six clubs entered the final day of the Ligue 2 season with a chance at winning the title, but Strasbourg came out on top with a 2-0 with over Bourg en Bresse Peronnas, edging Amiens and Troyes by a single point.
The promotion is Strasbourg's fourth in six years after they were sent to the fifth tier following bankruptcy issues in 2011. They last played in the top flight in 2008.
Ligue 1 leaders Monaco will face a trip to Marseille in the Coupe de France round of 16.
Thursday's draw, for matches to be played on Feb. 28 and March 1, also gave Paris Saint-Germain a match away from home at Ligue 2's Niort.
The only other fixture between top-flight sides sees Bordeaux at home against Lorient.
The two fourth-tier teams still playing will also be at home, with Bergerac Perigord facing Lille, and Frejus hosting Auxerre.
Coupe de France round of 16 draw: