Southend will be without Jason Demetriou and Harry Kyprianou for the visit of Rotherham in Sky Bet League One.
Demetriou and Kyprianou have received call-ups to the Cyprus and Cyprus Under-21 squads respectively so will be unavailable for the Shrimpers.
Boss Chris Powell will consider Elvis Bwomono or John White as replacements.
Michael Kightly is likely to come back into the side after he was rested at Blackpool last week.
Rotherham goalkeeper Marek Rodak is on international duty with Slovakia Under-21s.