M'Baye Leye scored the only goal of the game as Lokeren condemned Metalist Kharkiv to a sixth consecutive defeat in Europa League Group L.
Neither had anything tangible to play for in this final outing, with Lokeren unable to sneak into the Round of 32 and their Ukrainian hosts rooted to the foot of the table.
Metalist might have salvaged some pride had they registered a first point but Leye's 15th-minute header and a resolute goalkeeping performance from Boubacar Barry ensured that would not happen.
Lokeren ended Group L leaders Legia Warsaw's 100 per cent Europa League record with an impressive win - but it was not enough to keep their qualification hopes alive.
Hans Vanaken's seventh-minute goal settled the match in the hosts' favour.
But Trabzonspor beat Metalist Kharkiv 3-1 to remain three points ahead of Peter Maes' side, with the crucial head-to-head advantage in their favour.
Legia had won their first four games in the group and began this one on the front foot, Lukasz Broz firing wide...
Trabzonspor held Lokeren to a 1-1 draw in Belgium to improve their chances of making it into the knockout stages of the Europa League.
With Legia Warsaw through and Metalist Kharkiv without a point from four games, the battle for the other qualification spot in Group L will come down to these two.
And the Turkish side are three points clear of their rivals from East Flanders after Abdul Majeed Waris cancelled out Ayanda Patosi's early goal.
Lokeren got off to the best possible start as they went ahead...