Annan are without defender Steven Swinglehurst and striker Kenny Mackay when East Stirling visit Galabank
Manager Jim Chapman is looking for his side to bounce back from losing 1-0 to leaders Arbroath on Tuesday.
Chapman said: "We played well in that game especially in the second half and deserved to take something from it.
"Unfortunately it never happened for us in front of goal, however we have the chance to put that right against East Stirling.
"We had been on a decent run up until the Arbroath game...