Paul Lewis is looking to make his debut when Cambridge welcome Mansfield in Sky Bet League Two.
The 22-year-old former Macclesfield midfielder was an unused substitute in the 0-0 draw with Blackpool last weekend but is pushing for a start.
Defender Scott Wharton, signed on loan from Blackburn, will also be considered by manager Shaun Derry.
Blair Adams could start at right-back if Brad Halliday (knee) does not pass a late fitness test but Greg Taylor (groin) is definitely out.
Shaq Coulthirst should...