Alexis Sanchez says he is "tired" of being criticised by the media and that it is affecting him.
The Arsenal forward, at the centre of transfer window speculation this summer with Manchester City among his admirers, received poor reviews after another below-par performance on Tuesday with Chile.
Sanchez, who was one booking away from suspension, started for Chile in the encounter in La Paz and received a yellow card in the 83rd minute of his team's 1-0 defeat at Bolivia. He will therefore miss next month's qualifier against Ecuador.
That setback to Bolivia followed last week's shock 3-0 home loss to Paraguay and has left the national team's hopes of qualifying for the 2018 World Cup in jeopardy.
La Tercera newspaper was unimpressed with Sanchez's display, writing: "In La Paz, he extended the insignificance he had against Paraguay. He never understood how the game had to be played ... To make matters worse, he got a yellow card that leaves him out of the game against Ecuador."
El Grafico Chile wrote: "Completely disconnected, lost in La Paz."
Sanchez responded on Instagram after Tuesday's loss, writing: "AND THE TIME COMES WHEN YOU GET TIRED. Tired of being criticised with and without a reason, tired that they want to see you defeated, tired of telling yourself 'once more I will get up' after crying following a defeat and you are tired of telling the world and those people around you that all is well.
"And worst of all is that no one realises how that makes you feel....I wear Chile's number 7 jersey and that brings an enormous responsibility, that is why I'm sad that journalists and bad people criticise without knowing..."
Sanchez's former under-20 coach Jose Sulantay had questioned the Arsenal star after the Paraguay contest, a game that was played hours after the transfer window had shut in Europe.
He said that Sanchez, who missed the start of the season with an abdominal injury, was "more worried about his situation at Arsenal" than about the qualifier and that he was "overweight and fat."
Chile have dropped to sixth in CONMEBOL qualifying, two places and one point adrift of fifth place, the intercontinental playoff spot currently occupied by Argentina.
Argentina are level on 24 points with Peru, who are fourth with two qualifying games remaining.
Only the top four sides will qualify directly for the tournament that is to be staged in Russia.
Chile, coached by Juan Antonio Pizzi, resume their qualifying campaign at home to Ecuador on Oct. 5 before taking on Group leaders Brazil five days later in Sao Paulo.