Aston Villa and Queens Park Rangers both suffered nights to forget after being dumped out of the Capital One Cup second round by Leyton Orient and Burton Albion respectively.
Orient become the latest lower league team to inflict more cup misery on Villa, winning 1-0 at Villa Park.
Romain Vincelot's header three minutes from time sees the League One side join Bradford in humiliating Villa in this competition, with the Bantams famously defeating the Premier League team over a two-legged semi-final in 2013.
And earlier this year at Villa Park, Sheffield United knocked Paul Lambert's men out of the FA Cup.
Adam McGurk struck a superb late free-kick as League Two side Burton claimed a shock 1-0 win over QPR.
The Brewers striker, who recovered from a hip injury to feature, rewarded the hosts for a bright performance as he curled home a fine set piece with just 13 minutes remaining at the Pirelli Stadium.
QPR's Junior Hoilett hit the bar before the break but the Londoners did not look like winning for a first time this season as the game wore on.
Instead they became the latest top-flight side to pay the penalty for making multiple changes in the competition and produced a lacklustre display.
It was a better night for Sunderland as their late show sent them through to the third round with a 3-0 win, leaving Birmingham fuming.
Jordi Gomez, Adam Johnson and Connor Wickham struck in the final 13 minutes to stun the hosts and give the Premier League side a 3-0 win.
However, the Blues were angered after Gomez's opener, claiming the ball had gone out in the build-up.
Jonathan Walters scored twice and made a late third for Peter Crouch to ease Stoke City into the next round as on-loan Chelsea winger Victor Moses enjoyed a promising debut in the 3-0 win against Portsmouth at the Britannia Stadium.
While the prospect of seeing Moses -- who had not started a club game since scoring for Liverpool in an FA Cup fourth round tie at Bournemouth in January -- for the first time hardly enticed the locals to the game in their droves, there were some encouraging elements to be seen in a 3-0 victory.
Aside from some threatening runs from the Nigeria international, the display by Marc Muniesa at left-back, one of nine changes from Sunday's Premier League draw at Hull, was another positive as was the late debut handed to 16-year-old academy graduate Oliver Shenton.
Elsewhere, James Hanson's late winner heaped further pressure on Leeds head coach Dave Hockaday as Bradford claimed a 2-1 victory in a fiery West Yorkshire derby.
Hockaday, who was given a stay of execution by club president Massimo Cellino following Saturday's 4-1 defeat at Watford, looked a relieved man when Matt Smith headed his side in front eight minutes from time.
But a stunning equaliser from Billy Knott soon lifted the home crowd again, and they were simply delirious when Hanson prodded over the line with four minutes remaining.