Arsenal and Chelsea will meet in a mouthwatering Capital One Cup fourth round clash, while Manchester United and Manchester City have both drawn Premier League opposition.
Jose Mourinho's side will travel to the Emirates Stadium after Arsenal defeated West Brom on penalties on Wednesday night.
United, who knocked Liverpool out of the competition thanks to Javier Hernandez's goal, will host Norwich City, while Manuel Pellegrini's City travel to St James' Park to face Newcastle United.
Two other all-Premier League fixtures see Tottenham play Hull and Sunderland host Southampton.
Fulham were drawn a trip to Championship side Leicester City and Stoke are pitted against Birmingham City, who knocked holders Swansea out in the third round.
Elsewhere, West Ham will be expected to progress when they take on Burnley.
All matches will be played on the week of October 28.