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1:00 AM UTC Dec 4, 2016
Leg 2Aggregate: 1 - 0
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Real Madrid shopping Isco out to Man City, Arsenal and Manchester United?

Isco appears to be on the outer at the Bernabeu -- something that has triggered plenty of interest in the Premier League.

The winter window might have shut, but the rumour mill rolls on. As always, Transfer Talk has its finger on the pulse when it comes to the latest rumours and gossip. See the latest deals here.

Top story: Premier League clubs on red alert for Isco

Real Madrid are set to put Premier League clubs on red alert after deciding to sell Spanish star Isco this summer.

Manchester City, Arsenal and Manchester United are all keeping a close eye on proceedings, and the Mirror reports that Real Madrid will demand around £25 million for the playmaker.

City were keen on the 23-year-old Isco the summer he moved to Real Madrid from Malaga, as well as in January, and whether they relaunch a deal will depend on new boss Pep Guardiola. United and Arsenal are looking to strengthen their squads and both have looked at him in the past. Chelsea also could be interested as they look to rebuild with Italy boss Antonio Conte poised to take charge at Stamford Bridge this summer.

Isco has had a difficult season, but Real were keen for him to stay and progress under new boss Zinedine Zidane. However, his underwhelming performances since the turn of the year have changed their stance, and they now appear ready to cut their losses and sell with the Premier League looking like the most likely destination.

Arsenal to go for Gundogan

According to German outlet Bild, Arsenal are plotting a move for Ilkay Gundogan this summer. Gundogan's contract runs out in June 2017, but after coming close to leaving the club last year, and after enjoying five successful seasons in Dortmund, he is set to seek a new adventure.

The report claims that Arsenal are among many teams chasing the midfield star, with Manchester City and Barcelona also interested in the 25-year-old.

With Tomas Rosicky, Mikel Arteta and Mathieu Flamini set to leave the club in July after their contracts expire, in addition to the uncertainty around the future of Aaron Ramsey, Gundogan could be the perfect acquisition for the Gunners as they prepare to rebuild yet again after another squad overhaul.

Ronaldo, Ramos on the way out?

Gab Marcotti reacts to the speculation that both Cristiano Ronaldo and Sergio Ramos have handed in transfer requests at Real Madrid:

United step up Saul interest

Manchester United are stepping up their interest in Saul Niguez, after he reportedly rejected a contract extension at Atletico Madrid.

The 21-year-old has been linked to United in the past two transfer windows, and it is believed that Old Trafford scouts have been watching him extensively -- which is why the Mirror says the Spanish club are so keen to tie him down to a new deal.

Atletico already have Saul signed on a deal until 2020, which includes a £25 million buyout clause, but United see this as a perfect opportunity to move in this summer amid a contract stand-off. The Spanish international has become more of a first-team regular this season, earning the trust of his manager Diego Simeone with a string of dynamic displays as they look to challenge Barcelona for the title.

Chelsea and Conte look to Pjanic

In a mission to bolster their midfield, Chelsea are looking to Roma midfielder Miralem Pjanic, reports The Times. Marina Granovskaia, Chelsea's director and lead negotiator, has spoken to the Bosnian's advisers and established that there is a £31 million buyout clause in the 25 year-old's contract at Roma.

Pjanic is one of the players recommended by Antonio Conte, the Italy coach who is expected to be named the new Chelsea manager this month, along with his Roma teammate Radja Nainggolan.

After moving to the Italian capital in 2011 from Lyon, Pjanic has become one of the most decorated midfielders in Europe, impressing with his passing, long-range shooting and set piece ability.

Tap-Ins

- Manchester City and Manchester United are set to battle it out this summer after both clubs have identified West ham defender Angelo Ogbonna as a possible target, according to the Times.

- Barcelona star Lionel Messi, similarly to Sergio Aguero, has revealed that he would like to return to his homeland Argentina at some stage of his career.

- West Brom are lining up a £2 million summer move for Bristol City's giant defender Aden Flint. The Mirror reports that Albion boss Tony Pulis has sent scouts to watch the 6-foot-7 centre-half who has gained a reputation for being a goalscoring defender.

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