Alexis Sanchez and Aguero lead the way, Ulloa and Mahrez to step up?
Leicester stuttered, Spurs swooped and Villa finally went down -- ESPN FC Premier Fantasy's double Gameweek 34 was a big deal at both ends of the table.
This weekend's reduced seven-match schedule is just as key, with the top two and three of the bottom four in action.
GW34's midweek action brought a hefty slice of big points-scoring.
Arsenal's Alexis Sanchez (£9.7m) added a brace against West Brom to his goal against Crystal Palace for a 25-point haul, while Sergio Aguero (£10.4m) hit his fourth goal in two matches to amass 22 points overall.
West Ham skipper Mark Noble (£6.4m) saved his best for Wednesday's 3-1 win over Watford, scoring two penalties for 15 points and a 17-point two-match total.
Antonio Valencia (£5.1m) emerged as Man United's top double Gameweek asset, with 17 points across two clean sheets and an assist, but Matteo Darmian (£6.0m) ran him close with a goal, a clean sheet and 14 points from the 2-0 midweek win over Palace.
Liverpool reacted positively to their Europa League heroics with back-to-back wins that included a 4-0 dismantling of Everton. Mamadou Sakho (£5.5m) was the derby day stand-out, with 15 points from a goal and a clean sheet and 16 points overall.
With the pressure off, is it time for Villa to start performing? Probably not, so drafting in some key Southampton players for their home match with the Premier League's first casualty of the season looks wise.
Strikers Graziano Pelle (£7.1m) and Shane Long (£7.4m) are in fine form. The former has four goals and three assists in his last five starts, while the latter has a goal and an assist from his last two.
Virgil van Dijk (£7.1m) is the Saints' leading defender this season, in the top 10 with 144 points. The Saints haven't kept a clean sheet for eight matches, but Villa have the league's second-worst record of 11 goals on the road.
Villa are one of only five teams to have scored fewer times than Swansea away from home, so a trip to Leicester looks good... for the league leaders.
By his own stellar standards, Riyad Mahrez (£9.7m) has been quiet of late, with two goals in his last six starts. Now that Jamie Vardy (£10.2m) is out for at least one match, Mahrez needs to step up.
The Foxes' defence has been in title-winning form, with the two goals they conceded against West Ham breaking a run of five consecutive clean sheets. Christian Fuchs (£7.3m) is a key member of that brilliant back four and he also offers an attacking threat, with four assists this season, three of which have come in 2016.
Tottenham host West Brom on Monday and have a wealth of in-form players ready to keep the pressure on Leicester.
Dele Alli (£7.4m) has scored three goals in his last two matches (and has four assists in six), while Christian Eriksen (£8.5m) has four assists in three matches and a very healthy 14 for the season. Another midfielder, Erik Lamela (£6.9m) is also worth a look on the back of 20 points from a goal and two assists from his last two starts.
At the back, ESPN FC Premier Fantasy's leading defender Toby Alderweireld (£7.7m) has marshalled a backline that's kept four clean sheets out of five.
Liverpool's home match with Newcastle should be a routine win for the Reds, but squad rotation ahead of next week's Europa League semifinal and the Magpies' up-turn in form are clouding the issue.
The ankle injury Divock Origi (£6.7m) sustained in the Merseyside derby should at least settle the question of who starts up front, with Daniel Sturridge (£9.1m) firmly in that particular frame. And with three goals in as many league matches, he's in form.
Roberto Firmino (£7.9m) has been subbed off no later than the 75th minute in the last three league matches, suggesting he is being managed to start as many times as possible -- particularly as Liverpool still have a genuine chance of making the top four this season.
Aguero has six goals in four league matches and is surely too important to rest ahead of Man City's Champions League semifinal. Visitors Stoke have shipped 10 goals in their last three matches and haven't kept an away clean sheet since Dec. 12. Manuel Pellegrini will hope for quick goals and an early finish for his star man.
Sanchez has been the Gunners' main man for weeks, making a telling contribution in seven consecutive matches. A trip to an improving Sunderland desperate for points will be tough, but Sanchez has the class to continue his excellent run.
The league's leading scorer, Harry Kane (£9.8m), has eight goals from his last six starts and faces West Brom next. The Baggies will have travelled to all of the top four since the start of March once the Spurs fixture is done, and they're currently conceding at least two goals a match. Kane will fancy his chances.
A SINGLE PUNT
With Vardy out, Leonardo Ulloa (£4.7m) is likely to lead the Leicester line against Swansea. A key man in the Foxes' great escape last season, he recorded 11 goals and three assists from 29 starts.
Vardy's incredible run has reduced the Argentine to just five starts this time around, but he's still chipped in with four goals and two assists and he's actually looking sharper. His shot accuracy is up from 36.7 percent to 38 percent, his minutes per attempt has improved from 51 to 42 and his minutes per goal average has gone from 227 to 220.
His last-gasp penalty against West Ham last weekend shows he is the man for the big moment and his 0.6 percent ownership stats suggest he could be a very handy difference-maker.