Arsenal battled to a 2-2 draw in the North London derby at Tottenham Hotspur despite seeing Francis Coquelin sent off early in the second half.
Second-placed Spurs began the day three points clear of Arsenal and had been on course to effectively end their arch-rivals' Premier League title hopes when they scored two quickfire goals after Coquelin had seen red, but Alexis Sanchez's 76th-minute goal gave the Gunners a share of the spoils.
Arsenal scored against the run of play on 39 minutes, Aaron Ramsey producing a superb flick from Hector Bellerin's pass to send the ball past Hugo Lloris, sparking the visitors' best period of the game.
Within 10 minutes of the restart, though, the momentum shifted firmly back towards Spurs as Coquelin was shown a second yellow card for a foul on Harry Kane.
Toby Alderweireld fired past David Ospina following a corner on the hour mark, and Kane then sent a superb strike into the top corner from out wide two minutes later.
The Gunners once more silenced White Hart Lane with just under 15 minutes remaining as Sanchez slid the ball past Lloris into the bottom corner to secure a share of the spoils.
Riyad Mahrez scored to put Leicester five points clear atop the Premier League with a 1-0 win at Watford on Saturday.
The breakthrough came in the 56th minute when Watford defender Jose Holebas could only half-clear a cross back to the top of the box, where Mahrez controlled the ball and picked his spot inside the post.
Watford's best chance for an equaliser came in the 80th minute when Odion Ighalo could manage only a soft touch to an open header from six yards.
There was a scary moment for Leicester when Mahrez pulled up and grabbed his hamstring. He was able to jog afterward but was soon replaced by Daniel Amartey.
Manchester City ended a run of three consecutive Premier League defeats with a 4-0 victory over rock-bottom Aston Villa.
City, who had been held to a goalless draw at Villa Park earlier this season, dominated the early stages but were unable to find a way through.
The hosts finally broke Villa's resistance at the start of the second half, with Yaya Toure sweeping home the opener on 48 minutes.
Two minutes later it was 2-0, Sergio Aguero deflecting the ball past Brad Guzan from former City defender Micah Richards' attempted clearance. On the hour, Aguero netted his second as he combined superbly with David Silva.
Raheem Sterling made it four shortly after coming off the bench, turning home a Jesus Navas cross at the back post.
Aguero could have completed his hat trick when he was presented with a penalty following a foul on Kelechi Iheanacho, but the Argentina international struck the post.
Chelsea were denied a fourth successive Premier League win as Stoke City came from behind to record a 1-1 draw at Stamford Bridge.
Bertrand Traore, selected to lead the attack in the absence of Diego Costa, rewarded Guus Hiddink's faith by breaking the deadlock on 39 minutes, sending the ball past Jack Butland from the edge of the area.
Xherdan Shaqiri threatened an equaliser on 59 minutes but was denied by a superb Thibaut Courtois save.
However, Courtois failed to deal with a Shaqiri cross five minutes before the end, allowing Mame Biram Diouf to head home, keeping Stoke three points clear of their hosts.
West Ham United remain a point away from the top four after they came back from two goals down to beat 10-man Everton 3-2 at Goodison Park.
West Ham went into the match on the back of two successive wins that had moved them within a point of fourth, but they fell behind to Romelu Lukaku's fine low finish on 14 minutes.
Everton saw Kevin Mirallas sent off on 34 minutes, picking up a second yellow card for a foul on Aaron Cresswell, but they extended their advantage in the second half when Lukaku combined with Aaron Lennon, with the winger slotting home.
Everton might have extended their lead when Muhamed Besic was fouled by Alex Song in the area but Lukaku's spot kick was saved by Adrian, and the miss proved costly.
Michail Antonio headed home on 78 minutes for his fifth goal in his last eight games, and he then turned provider for Diafra Sakho to level it three minutes later.
Dimitri Payet then scored in the 90th minute to complete a superb comeback for Slaven Bilic's men.
Bournemouth beat Newcastle United 3-1 at St James' Park as Steve McClaren's side suffered a fifth defeat in six games.
McClaren had been in desperate need of a victory, with the club second bottom in the table and his own future the subject of media speculation, but they fell behind when Steven Taylor deflected Josh King's cross into his own net on 28 minutes.
The home fans chanted "You're getting sacked in the morning" before King made it 2-0 in the 70th minute, slamming the ball past Rob Elliot in the Newcastle goal.
Ayoze Perez pulled one back on 81 minutes, but Charlie Daniels added a third in injury time to deepen McClaren's misery.
Swansea City took a big step towards safety with a 1-0 victory over a Norwich City side in freefall.
The match, watched by new FIFA president Gianni Infantino after he attended an IFAB meeting in Wales, saw little action in the first half as Swansea sought to build on their surprise win at Arsenal in midweek.
Gylfi Sigurdsson gave the hosts the advantage on 61 minutes after good work from former Norwich midfielder Leroy Fer, condemning the Canaries to a ninth defeat in 10 league games.
Sunderland were denied victory over 10-man Southampton by a late Virgil van Dijk equaliser in a 1-1 draw at St Mary's.
Southampton saw Jose Fonte sent off on 79 minutes for bringing down Fabio Borini when through on goal, and Jermain Defoe broke the deadlock six minutes later.
However, Dusan Tadic set up Van Dijk to salvage a point for Saints with an injury-time equaliser.
The draw keeps Sunderland in 17th but sees them move a point clear of Norwich and Newcastle.