Arsenal start Mohamed Elneny, Danny Welbeck; Dele Alli back for Spurs
Arsenal have brought in Mohamed Elneny against Tottenham while goalkeeper David Ospina comes in to replace the injured Petr Cech.
The Gunners are without centre-back Laurent Koscielny (calf) and are also missing midfielders Jack Wilshere (leg), Tomas Rosicky (thigh), Santi Cazorla (knee) and Alex Oxlade-Chamberlain (knee).
Gabriel comes in for Koscielny in defence, and Kieran Gibbs takes the place of Nacho Monreal.
Danny Welbeck takes his place up front with Theo Walcott dropped to the bench after a poor showing against Swansea and Olivier Giroud also left out.
Tottenham have been handed a double boost in midfield as Dele Alli returns from an ankle injury after he came off the bench against West Ham on Wednesday, and Mousa Dembele overcame a groin strain to start.
Mauricio Pochettino has opted for Danny Rose at left-back, with Harry Kane starting up front with Erik Lamela and Christian Eriksen supporting him.
Clinton Njie and Jan Vertonghen (both knee) are missing for the home side.