Per Mertesacker and Laurent Koscielny both miss out for Arsenal against Liverpool, who have named Roberto Firmino for a first Premier League start.
Gabriel and Calum Chambers fill in for experienced duo Mertesacker and Koscielny, who are out with illness and a back problem respectively, in the centre of defence at Emirates Stadium.
Liverpool captain Jordan Henderson is absent while Adam Lallana also misses out for Brendan Rodgers' side.
Firmino signed for the Reds for £29 million from Hoffenheim in the summer and has so far made two appearances from the substitutes' bench.
Lucas Leiva comes into midfield for Liverpool as Lallana has been struggling with a thigh problem.