Andy Carroll left St Mary's on crutches after West Ham impressively held out at Southampton despite Adrian's dismissal, a red card manager Sam Allardyce will be appealing.
If the east London side felt robbed by Manchester United on Sunday, it was Saints this time ruing missed opportunities after dominating possession and the shot count.
The hosts also had a man advantage from the 61st minute onwards after a moment of madness from West Ham goalkeeper Adrian, who attempted to turn away from Sadio Mane, who was caught out and handled outside the box.
The Spaniard was given a straight red card, but it didn't cost his side. Replacement Jussi Jaaskelainen produced some fine saves and a number of chances also went well wide, as West Ham dug deep to secure a 0-0 draw.
"I think that from our point of view it almost feels like a victory against all the odds," Allardyce said .
"I think the lads who ended up on the field, apart from Andy who was injured, have done a fantastic job."
Carroll was a second-half substitute at St Mary's, where he made his return from an injury picked up in the defeat to Liverpool, but he left the stadium on crutches and Allardyce said he does not know the severity of his injury.
"The sad thing for us is the injury to Andy Carroll, which we can ill-afford to take with our injury problems," Allardyce said.
"It's the same knee, he got kicked in the back of the knee and felt something wrong.
"He stayed up and was a nuisance. I just hope that staying on hasn't done any more damage.
"He got fit in two and a half weeks [after Liverpool], but clearly it's going to take longer this time because it's the same injury."
While Carroll faces time out, Adrian may not after Allardyce confirmed West Ham would be appeal referee Craig Pawson's decision.
"It was a foul on our goalkeeper before," he said. "There is no doubt Mane had his hands on Adrian.
"Adrian made a mistake in the beginning, but the linesman saw two hands on the ball but not the two hands on the back.
"We will be appealing it and I'll be very disappointed if he doesn't get off."