Liverpool manager Brendan Rodgers has voiced concern that his side lack the depth to cope with the absence of Daniel Sturridge for up to two months.
• Usher: Sturridge-less Reds lose
In addition, Liverpool were only able to use Philippe Coutinho as a substitute as he continues to recover from his own ankle problems.
And after watching his side produce one of their poorest performances of the season against an often inspired home side, Rodgers said: “The quality of our squad isn't big enough to cope with two big players like that missing. No doubt it was a disruption.
“Daniel is out for up to eight weeks, which is a big blow for us, and Phillipe didn't train all week. He had injections just to get on the bench.
“It's difficult if you take those two out, two players who have been very efficient for us this season. This little period will test us now, but players will come in and it's a great opportunity to a stake a claim.
“We have a very busy period coming up and we've got a squad that needs as many of its good players as possible, so it's not ideal.” Rodgers said Sturridge had suffered an ankle strain in training after he “just slipped on the surface.”
“We thought initially it was the toe, but he went straight to the medics and was getting a scan before the end of training,” he added. “He'll be disappointed, and it is a big blow for us.”
Rodgers could not hide his frustration at Liverpool’s performance, saying: “We went into the game with confidence and belief, but we made too many mistakes with and without the ball.
“We lacked quality with the ball, we never created enough and never kept the ball long enough. I always felt we were in control of the game, but we needed to show more quality and penetrate a wee bit more.”
His Hull counterpart Steve Bruce said he was delighted with the way in which his players had bounced back from their home defeat to Crystal Palace the previous week, adding: “I said last week was the most disappointing since the start of the season because the expectation was to roll over Crystal Palace and we didn't play well at all.
“It was important to get a response. I knew there would be one because it was Liverpool at home, and you need a game like that sometimes.
“Let's be fair -- Liverpool have better players than we have. But the big thing was the response of the team after the disappointment last week, and they showed that.”
Information from the Press Association was used in this report.