City and United clash in Manchester derby, Arsenal face Everton
Out-of-form Manchester City host rivals Manchester United in a battle for Champions League qualification while Arsenal look to keep their faint Premier League title hopes alive at Everton.
At the wrong end of the table, relegation-threatened pair Newcastle United and Sunderland face off in the Tyne-Wear derby, as Rafa Benitez takes charge of the Magpies for the first time at St James' Park.
Have your say on each match's outcome by voting in our match polls.
MAN CITY: A Manchester derby that pitches a shot-shy attack (United) against a makeshift defence (City) should at least conjure some moments of high drama -- if not high quality. City start as favourites in what is now a fight for third.
Prediction: Manchester City 2-1 Manchester United -- Simon Curtis
MAN UNITED: Vincent Kompany's absence is a huge boost, but there are questions over whether United's inexperienced forward line will be able to take advantage. This City team should have walked to the title once Chelsea bowed out early on, judging on the quality of their squad, and you imagine they'll turn it on for derby day.
Prediction: Manchester City 2-1 Manchester United -- Scott Patterson
EVERTON: Defeat to West Ham and FA Cup success over Chelsea showed the two sides of an inconsistent Everton in successive home games. The Blues will want to replicate the latter but must do without suspended Gareth Barry and Kevin Mirallas against Arsenal.
Prediction: Everton 1-1 Arsenal -- Luke O'Farrell
ARSENAL: Despite losing 3-1 in Barcelona, there were some encouraging signs, and if Danny Welbeck and Alex Iwobi are both included from the start again it should give Arsenal renewed dynamism in the final third -- which is desperately needed. It's been a demanding week but Arsenal should get back on track.
Prediction: Everton 1-2 Arsenal -- Tom Adams
CRYSTAL PALACE: Palace still haven't worked out how to turn their FA Cup form into league wins in 2016 but with Connor Wickham back, expect them to upset the world by beating everyone's second team, Leicester. It would be the most Palace thing to do.
Prediction: Crystal Palace 2-1 Leicester -- Jim Daly
LEICESTER: With Spurs not in action until Sunday, Leicester can go eight clear at the top. No away game is easy, but having limped past Newcastle, another win will give Leicester breathing pace and support Sir Alex Ferguson's theory that the Foxes can wrap up the title with games to spare. Palace have lost their past three games at home 2-1 -- a repeat could be on the cards.
Prediction: Crystal Palace 1-2 Leicester -- Ben Jacobs
CHELSEA: Against West Ham, with little more to play for other than pride, interim boss Guus Hiddink is expected to shuffle his XI to accommodate younger players. The result will likely be a convincing victory for the Blues, and more frustration for their fans who have been clamouring for the youth to be given a chance.
Prediction: Chelsea 2-0 West Ham -- Mark Worrall
WEST HAM: Chelsea will be smarting from their FA Cup exit and keen to gain revenge for the league defeat at Upton Park last October that hastened the end for Jose Mourinho. The Hammers' confidence is high, though, and an attractive draw is the most likely result.
Prediction: Chelsea 1-1 West Ham -- Peter Thorne
TOTTENHAM: Bournemouth are on a good run of form and have all but guaranteed their survival. The pressure, then, is all on Spurs who need the three points more than their visitors. An early Spurs goal would go a long way to settle nerves, but Tottenham should have enough quality to win ugly if necessary.
Prediction: Tottenham 3-1 Bournemoutth -- John Crace
BOURNEMOUTH: The club are surely staying up and head to title contenders Spurs looking to put in a better showing than the 5-1 home rout last October. Goals are starting to flow again and Eddie Howe's team could cause problems. Up front, in-form Norwegian striker Josh King is the main threat.
Prediction: Tottenham 3-2 Bournemoutth -- Steve Menary
SOUTHAMPTON: Liverpool were responsible for inflicting the most one-sided defeat of Ronald Koeman's reign at St Mary's, a 6-1 League Cup thrashing earlier in the season. Southampton have improved defensively since then and much will depend on whether Graziano Pelle can pick up where he left off last weekend at Stoke.
Prediction: Southampton 1-1 Liverpool -- Alex Crook
LIVERPOOL: Erratic league form from both sides makes this a difficult game to predict. Much will depend on Liverpool's mood once they emerge from their midweek battle with Man United, but a win at St Mary's could mean more futile dreaming of a Champions League place for a few weeks longer.
Prediction: Southampton 1-2 Liverpool -- Steven Kelly
NEWCASTLE UNITED: Never before in Premier League history has so much ridden on the outcome of this fixture between Newcastle and Sunderland. The losers will face an almighty challenge to avoid relegation, meaning the derby winners could enjoy bragging rights for many a year to come. I expect this to be close, but Newcastle will just pinch it.
Prediction: Newcastle 2-1 Sunderland -- Lee Ryder
SUNDERLAND: The visit to fellow strugglers Newcastle may be the most important Tyne-Wear derby in history. Sam Allardyce's team clung to fourth bottom despite not playing last weekend, but the potential effect of Rafa Benitez's arrival at Newcastle is ominous. Either Magpies midfielder Moussa Sissoko or Sunderland striker Jermain Defoe could be decisive.
Prediction: Newcastle 0-1 Sunderland -- Colin Randall
SWANSEA: Swansea will be hoping to bounce back from their defeat to Bournemouth by taking Aston Villa to task. Doomed Villa haven't won in five games and have both the league's worst defence and worst attack. Provided Swansea don't get complacent, this could be the game the floodgates finally open for Alberto Paloschi.
Prediction: Swansea 3-0 Aston Villa -- Max Hicks
ASTON VILLA: Villa have never won this Premier League fixture, losing two and drawing two of four previous visits to the Liberty Stadium. Another Swansea victory would just about make them safe from relegation. Villa, under Remi Garde, have found scant motivation for weeks and may offer only token resistance.
Prediction: Swansea 2-1 Aston Villa -- Kevin Hughes
WEST BROM: West Brom return from a two-week break looking to go past the 40-point barrier against Norwich at The Hawthorns. Salomon Rondon scored the winner in the reverse fixture earlier this season and will be looking to continue his recent good form in front of goal.
Prediction: West Brom 2-0 Norwich -- Matthew Evans
NORWICH: Norwich earned plaudits for the manner of their battling 0-0 draw against Manchester City last time out. But survival hinges on wins, and facing a Baggies side who are all but safe is a prime opportunity to harness real momentum for the run-in by getting points on the board.
Prediction: West Brom 1-2 Norwich -- Paddy Davitt
WATFORD: Victory on Saturday would see the Hornets, who are currently 14th, reach the 40-point mark in mid-March, and while league form has been very patchy in 2016, confidence should be high following last weekend's excellent cup victory at Arsenal.
Prediction: Watford 2-1 Stoke -- Michael Moruzzi
STOKE: Stoke's 2-1 defeat to Southampton not only saw them lose three points, but also Ryan Shawcross and Xherdan Shaqiri to injury in advance of Saturday's trip to Watford. Marc Muniesa should get a recall to the defence, while Jon Walters will likely feature over on the right side of attack.
Prediction: Watford 1-1 Stoke -- James Whittaker